Dose-painted volumetric modulated arc therapy of high-grade glioma using 3,4-dihydroxy-6-[
| Autor: | Robert, Kosztyla, Srinivas, Raman, Vitali, Moiseenko, Stefan A, Reinsberg, Brian, Toyota, Alan, Nichol |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Aged 80 and over Male Organs at Risk Full Paper Brain Neoplasms Radiotherapy Planning Computer-Assisted Brain Radiotherapy Dosage Glioma Middle Aged Dihydroxyphenylalanine Tumor Burden Young Adult Positron-Emission Tomography Humans Female Radiotherapy Intensity-Modulated Aged Retrospective Studies |
| Zdroj: | Br J Radiol |
| ISSN: | 1748-880X |
| Popis: | OBJECTIVE: To determine whether dose painting with volumetric modulated arc therapy for high-grade gliomas using 3,4-dihydroxy-6-[(18)F]fluoro-l-phenylalanine ((18)F-FDOPA) positron emission tomography (PET) could achieve dose-escalated coverage of biological target volumes (BTVs) without increasing the dose to cranial organs at risk (OARs). METHODS: 10 patients with high-grade gliomas underwent CT, MRI, and (18)F-FDOPA PET/CT images for post-operative radiation therapy planning. Two volumetric modulated arc therapy plans were retrospectively generated for each patient: a conventional plan with 60 Gy in 30 fractions to the planning target volume delineated on MRI and a dose-escalated plan with a maximum dose of 80 Gy in 30 fractions to BTVs. BTVs were created by thresholding (18)F-FDOPA PET/CT uptake using a linear quadratic model that assumed tracer uptake was linearly related to tumour cell density. The maximum doses and equivalent uniform doses of OARs were compared. RESULTS: The median volume of the planning target volume receiving at least 95% of the prescribed dose (V (95%)) was 99.6% with and 99.5% without dose painting. The median V (95%) was >99.2% for BTVs. The maximum doses and equivalent uniform doses to the OARs did not differ significantly between the conventional and dose-painted plans. CONCLUSION: Using commercially available treatment planning software, dose painting for high-grade gliomas was feasible with good BTV coverage and no significant change in the dose to OARs. ADVANCES IN KNOWLEDGE: A novel treatment planning strategy was used to achieve dose painting for gliomas with BTVs obtained from (18)F-FDOPA PET/CT using a radiobiological model. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|