| Autor: |
C, Nordborg, V, Petursdottir |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Arthritis care and research : the official journal of the Arthritis Health Professions Association. 13(5) |
| ISSN: |
0893-7524 |
| Popis: |
To investigate morphometrically the relationship between the degree of inflammatory reaction and arterial cross-sectional dimensions in giant cell arteritis (GCA).The media and intima of cross-sectioned inflamed arteries from GCA patients were outlined. The media circumference and the media and intima cross-sectional areas were measured. The two segments in every biopsy displaying the least and most widespread media inflammation were compared, using a paired Student's t-test. Moreover, paired comparisons were made of the intima area in inflamed and noninflamed sectors in single cross-sections.The segment in each biopsy showing the most widespread media inflammation had the largest circumference and volume of media and intima; the intima cross-sectional area increased disproportionately. The intima was thickest in inflamed sectors in single cross-sections.The close spatial correlation between inflammatory media infiltration and the marked intimal expansion supports the contention that promoting factors produced by inflammatory cells play a pathogenetic role in GCA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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