Loss of blood isoantigens in exfoliated cells during the progression of CIN demonstrated by monoclonal antibody staining

Autor:	T R, Himes, C S, Ernst, I, Koprowska
Rok vydání:	1986
Předmět:	Immunoenzyme Techniques Vaginal Smears Isoantigens Staining and Labeling Histocytochemistry Blood Group Antigens Carcinoma Squamous Cell Antibodies Monoclonal Humans Uterine Cervical Neoplasms Female Neoplasm Invasiveness
Zdroj:	Acta cytologica. 30(5)
ISSN:	0001-5547
Popis:	The presence of isoantigens A, B and H in exfoliated cervical epithelial cells was readily demonstrable in cervical smears using monoclonal antibodies and an immunoperoxidase staining technique. The progressive decrease in the percentage of immunoperoxidase-positive dysplastic cells and in the proportion of cytologically normal squamous cells associated with these dysplastic cells reflected the loss of isoantigen expression that paralleled increasingly severe stages of cervical intraepithelial neoplasia. The loss of isoantigen expression in morphologically normal epithelial cells and in dysplastic cells may indicate that a particular patient is at greater risk of disease progression and that close follow-up is warranted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c92c34c2fbc58f134b84dd039a43da81 https://pubmed.ncbi.nlm.nih.gov/2430389 Zobrazit plný text záznamu