Intramuscular or combined intramuscular/intra-arterial administration of bone marrow mononuclear cells: a clinical trial in patients with advanced limb ischemia
| Autor: | R B, Van Tongeren, J F, Hamming, W E, Fibbe, V, Van Weel, S J G C, Frerichs, A M, Stiggelbout, J H, Van Bockel, J H, Lindeman |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Time Factors Brachial Artery Blood Pressure Recovery of Function Walking Intermittent Claudication Middle Aged Limb Salvage Injections Intramuscular Severity of Illness Index Amputation Surgical Treatment Outcome Injections Intra-Arterial Lower Extremity Ischemia Leukocytes Mononuclear Feasibility Studies Humans Female Ankle Aged Bone Marrow Transplantation Pain Measurement |
| Zdroj: | The Journal of cardiovascular surgery. 49(1) |
| ISSN: | 0021-9509 |
| Popis: | Recent evidence indicates that bone marrow mononuclear cells (BMC) promote collateral vessel formation in patients with severe peripheral arterial disease (PAD). However, aspects concerning optimal administration mode, durability and long-term safety require consideration. Combined intra-arterial (IA) plus intramuscular (IM) BMC delivery may be more effective than exclusive intramuscular injections. The aim of this study was to evaluate feasibility, safety and effect of exclusive IM versus combined IM+IA delivery of autologous BMC in patients who were not candidates for surgical or endovascular treatment.Twenty-seven patients were treated with either combined IA+IM (N=12) or sole IM (N=15) administration of autologous BMC. Efficacy was assessed after 1, 6 and 12 months. Limb salvage, pain-free walking distance, ankle-brachial pressure index (ABI) and pain scores were evaluated.There were no adverse reactions related to injection of the cells. Three patients died within the first year of follow-up due to non-procedure related causes. Two patients in the IA+IM group required limb amputation because of ongoing critical ischemia versus 7 patients in the IM group (P=0.17). BMC treatment in the remaining patients resulted in a significant and sustained (12 months) improvement. Pain-free walking distance improved from 81+/-56 meters at baseline to 257+/-126 meters at t=6 months (P=0.0002). Mean ABI increased 23% after 6 months (P=0.01) and pain score reduced for up to 50% as shown by Brief Pain Inventory (P=0.001).Both IM and combined IM/IA delivery of autologous BMC are safe, and result in relevant and sustained improvement in a considerable proportion of patients with severe PAD who are not amenable for conventional treatment. |
| Databáze: | OpenAIRE |
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