| Autor: |
Cleisson Schossler, Garcia, Evelyn Mianes, Besckow, Carlos Natã, da Silva Espíndola, Gustavo, D'Avila Nunes, Narryman Pinto, Zuge, Marcos Pizzatto, de Azeredo, Marcia Juciele da, Rocha, Luiz Roberto, Carraro Junior, Filipe, Penteado, Caroline Signorini, Gomes, Eder João, Lenardão, Cristiani Folharini, Bortolatto, César Augusto, Brüning |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
ACS chemical neuroscience. 13(12) |
| ISSN: |
1948-7193 |
| Popis: |
The monoaminergic dysfunction plays a central role in major depressive disorder (MDD), a mental disturbance associated with constant feeling of sadness and lack of interest. The available treatments do not present a desirable efficacy and some of them provoke several adverse effects. In this context, organoselenium compounds and molecules containing the indolizine nucleus have demonstrated interesting pharmacological properties, including antidepressant-like effects. In this study, the antidepressant-like effect of 2-phenyl-1-(phenylselanyl)indolizine (SeI), a selenium-containing indolizine derivative, was investigated on the forced swimming test (FST) and on the tail suspension test (TST) in male Swiss mice. The involvement of the serotonergic system in this effect was also accessed. The selenium compound SeI (10-100 mg/kg, intragastrical (i.g.)) was administered 0.5 h before the behavioral tests, and it diminished the immobility on both FST and TST experiments, which is an indication of antidepressant-like effect. No changing in the locomotor motion was observed in the open-field test (OFT). The anti-immobility effect of SeI was not altered by the preadministration of the selective serotonergic receptor antagonists ondansetron (1 mg/kg, intraperitoneally (i.p.), antagonist of 5-HT |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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