Cardioprotective effects of N-methylacetazolamide mediated by inhibition of L-type Ca

Autor:	Alejandro Ciocci, Pardo, Leandro A, Diaz Zegarra, Luisa F, González Arbeláez, Alejandro M, Ibáñez, Romina G, Díaz, Ernesto A, Aiello, Susana M, Mosca
Rok vydání:	2021
Předmět:	Cardiotonic Agents Calcium Channels L-Type Calcineurin Animals Methazolamide Myocardial Reperfusion Injury Myocytes Cardiac Calcium Channel Blockers Proto-Oncogene Proteins c-akt Rats
Zdroj:	Biochimica et biophysica acta. General subjects. 1866(5)
ISSN:	1872-8006
Popis:	Our objective was to examine the effects of N-methylacetazolamide (NMA), a non‑carbonic anhydrase inhibitor, on ischemia-reperfusion injury. Isolated rat hearts were assigned to the following groups: 1) Non-ischemic control (NIC):110 min of perfusion and 2) Ischemic control (IC): 30 min of global ischemia and 60 min of reperfusion (R). Both groups were repeated in presence of NMA (5 μM), administered during the first 10 min of R. Infarct size (IS) was measured by TTC staining. Developed pressure (LVDP) and end-diastolic pressure (LVEDP) of the left ventricle were used to assess systolic and diastolic function, respectively. The content of P-Akt, P-PKCε, P-Drp1 and calcineurin Aβ were measured. In cardiomyocytes the L-type Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::c7a932e2b2f323b47664ca57878d9231 https://pubmed.ncbi.nlm.nih.gov/35104623 Zobrazit plný text záznamu Full Text from ScienceDirect