Effects of Etanercept on TNF

Autor: Edgar, Mendieta-Condado, Elda Cristina, Villaseñor-Tapia, Francisco Javier, Gálvez-Gastelum, Irinea, Yáñez-Sánchez, Oscar, Pizano-Martínez, Alejandro, Canales-Aguirre, Ana Laura, Márquez-Aguirre
Rok vydání: 2022
Předmět:
Zdroj: BioMed research international. 2022
ISSN: 2314-6141
Popis: Chronic kidney disease (CKD) constitutes a chronic inflammatory state associated with an increase in inflammatory mediators and profibrotic molecules such as tumor necrosis factor-Rats were divided into three groups: control, renal injury model, and model plus ETA (2 mg/kg, 3 times per week (w); sc). Renal injury was induced by Ad administration (100 mg/kg, daily for 2 or 4 w; orogastric). Serum TNF-Ad administration produced a renal functional decline, tubular atrophy, interstitial inflammation, and fibrosis for 2 w, followed by renal anemia, several renal dysfunctions, tubular atrophy, and fibrosis at 4 w. A significant increase in serum TNF-Although inhibition of TNF by ETA was very effective in reducing serum TNF
Databáze: OpenAIRE
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