| Autor: |
Xiawen, Zheng, Yuejian, Chen, Zhiming, Wang, Lina, Song, Yu, Zhang, Ning, Gu, Fei, Xiong |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of nanoscience and nanotechnology. 19(6) |
| ISSN: |
1533-4880 |
| Popis: |
Through self-assembly of nanoparticles into high-order and stable structures of cubic clusters, high drug-loading rubik-like magnetic nano-assemblies (MNAs), possessing folic acid targeting and strong magnetism-enhanced cellular uptake capabilities, were built. In this study, the core of the cubic drug assemblies consisted of four monodisperse superparamagnetic iron oxide nanoparticles coated with layers of oleic acid (Fe₃O₄@OA), simultaneously encapsulating fluorescein, and Paclitaxol (Flu-MNAs and PTX-MNAs) for imaging and therapeutic applications. To enable preferential tumor cellular uptake by the nanocarriers, the outermost layer of Fe₃O₄ was functionalized with the new dual-oleic acid-polyethylene glycol-folic acid polymer (FA-PEG-Lys-OA₂) as a "shell." The drug carriers exhibited excellent stability and biocompatibility, and showed high drug loading and excellent magnetic response |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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