Basis for the anti-tumor and chemopreventive activities of glucarate and the glucarate:retinoid combination
| Autor: | H, Abou-Issa, C, Dwivedi, R W, Curley, R, Kirkpatrick, A, Koolemans-Beynen, F N, Engineer, K A, Humphries, W, el-Masry, T E, Webb |
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| Rok vydání: | 1993 |
| Předmět: |
Cell Cycle
Antineoplastic Agents Breast Neoplasms Drug Synergism Mammary Neoplasms Animal Tretinoin DNA Neoplasm Tritium Rats Rats Sprague-Dawley Glucaric Acid Retinoids Antineoplastic Combined Chemotherapy Protocols Tumor Cells Cultured Animals Anticarcinogenic Agents Humans Female Precancerous Conditions Cell Division Thymidine |
| Zdroj: | Anticancer research. 13(2) |
| ISSN: | 0250-7005 |
| Popis: | The biochemical basis for the cancer chemopreventive and anti-cancer activities of glucarate, retinoids (13-cis-retinoic acid, hydroxyphenyl retinamide) and their synergistic combination, has been evaluated. Neither alone nor in combination did these agents affect the level in the rat, of enzymes which are (a) known to correlate with reduced risk of carcinogenesis (detoxification enzyme, catalase, glutathione reductase) nor (b) enzymes which correlate with increased risk of carcinogenesis (beta-glucuronidase, xanthine oxidase, glucose-6-phosphate dehydrogenase). Retinoids, but neither glucarate nor its lactone inhibited free radical-induced lipid peroxidation. Both agents alone and synergistically in combination, raise cellular cAMP levels, repress protein kinase C and more generally inhibited DNA synthesis. |
| Databáze: | OpenAIRE |
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