| Autor: |
Lloyd Mills, C, Hallett, M B, McPherson, M A, Dormer, R L |
| Jazyk: |
angličtina |
| Rok vydání: |
1993 |
| Předmět: |
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| Popis: |
Increases in cytoplasmic free Ca2+ concentration in rat submandibular acini were observed in response to isoprenaline (10 microM), noradrenaline (10 microM) and carbamoylcholine (10 microM). Noradrenaline and carbamoylcholine responses were decreased to 27% and 33% respectively in the absence of extracellular Ca2+, suggesting a major requirement for Ca2+ entry. beta-Adrenergic stimulation elicited a small (35-40 nM) free Ca2+ rise, approx. 75% of which was mobilized from an intracellular store. Results suggest that this Ca2+ rise is a key event in the physiological triggering of mucin secretion by exocytosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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