| Autor: |
L C, Fernández Lisón, B, Vázquez Domínguez, F J, Rodríguez Gómez, A, Hevia Alonso, E, Pujol de la Llave |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Anales de medicina interna (Madrid, Spain : 1984). 23(12) |
| ISSN: |
0212-7199 |
| Popis: |
Describe the efficacy and safety of tenofovir.Observational, descriptive study. Data were analyzed for the intention-to-treat sample. The primary efficacy end-point included the proportion of patients with HIV-1 RNA level of 50 copies/ml or less. Secondary efficacy end points was the increase of the CD4 cell count at week 48. The primary safety end-point was the number of patients with abnormalities (clinical adverse events and laboratory toxicities). The causality of the adverse effects was measured by the Naranjo algorithm.154 subjects were enrolled; 12 were excluded from all analyses. Efficacy end points: Plasma HIV-1 RNA response: -1.29 +/- 0.97 log10 copies/ml; Patients with HIV-1 RNA levels of 50 copies/ml or less: 28.16%; CD4 cell count response: 40.27 +/- 141.50 cel/mm3. Safety profile was similar to showed at prescribing information, 3 Fanconi Syndrome were detected.Tenofovir supposes an antiretroviral of high effectiveness in our hospital, with an optimum safety profile. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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