| Autor: |
G V, Dziak, S N, Kolomiets, A I, Minakov, I M, Fushteĭ, O G, Iavorskiĭ, V F, Bekker, V N, Vankhanen, I V, Davydova, V I, Zaĭtseva, T V, Kolesnik, V V, Kolomiets, E P, Svishchenko, A I, Taran, N A, Shlykova, B, Barbich-Zhagar |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Terapevticheskii arkhiv. 71(1) |
| ISSN: |
0040-3660 |
| Popis: |
Assessment of efficiency and safety of enalapril (enap) and its combination with hydrochlorotiaside (enap-N).127 patients with mild and moderate blood hypertension entered an open non-comparative multicenter trial. 60 of them received enap (group 1), 67--enap N (group 2). Group 1 patients were given enap for 2 weeks in a dose 10 mg/day. If this dose was not adequate to normalize blood pressure, it was raised to 20-40 mg/day. Patients of group 2 received enap-N one tablet a day for 3 weeks. If the pressure persisted higher than 140/90 mm Hg, the treatment was continued for 3 weeks more in a dose of 2 tablets a day.Blood pressure lowered under 140/90 mm Hg in 40 patients of group 1 (66.7%). Systolic pressure dropped by 10 mm Hg minimum and diastolic by 5 mm minimum in 18 group 1 patients (30%). Enap-N reduced blood pressure under 140-90 mm Hg in 44 of 67 patients (65.7%). Systolic and diastolic pressure dropped, respectively, in 23(34.3%) patients.Enap and enap-N tablets were found highly effective and well tolerated. Side effects were caused by lowering of blood pressure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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