| Autor: |
J L, Adamany, G F, Cross, D, Gardner, M D, Dunning |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
The Journal of small animal practice. 58(7) |
| ISSN: |
1748-5827 |
| Popis: |
The influence of glucocorticoid therapy on bone resorption in dogs using a urine N-telopeptide assay was investigated.Thirty-one dogs receiving oral glucocorticoids and 31 age-matched healthy control dogs were enrolled. Urine N-telopeptide concentration was measured using a commercially available immunoassay and results were expressed as a ratio against urinary creatinine concentration. Dogs receiving glucocorticoids were divided into three subgroups based on daily glucocorticoid dose and three subgroups based on treatment duration. Urine N-telopeptide concentration was then compared between groups.Urine N-telopeptide concentration was significantly higher in dogs receiving glucocorticoids compared to the control group.This preliminary study demonstrates significant increase in urine N-telopeptide concentration in dogs receiving glucocorticoid therapy compared to control dogs. Further studies are needed to assess whether this increase in urine N-telopeptide concentration correlates with decreases in bone mineral density as has been identified in humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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