Calretinin expression as a critical component in the control of dentate gyrus long-term potentiation induction in mice

Autor:	H, Gurden, S N, Schiffmann, M, Lemaire, G A, Böhme, M, Parmentier, S, Schurmans
Rok vydání:	1998
Předmět:	Mice Inbred C57BL Mice Knockout Heterozygote Mice S100 Calcium Binding Protein G Calbindin 2 Dentate Gyrus Long-Term Potentiation Animals Nerve Tissue Proteins Eye Proteins
Zdroj:	The European journal of neuroscience. 10(9)
ISSN:	0953-816X
Popis:	We have recently reported that mice homozygous (Cr-/-) for a null mutation in the calretinin gene have impaired long-term potentiation (LTP) induction in the dentate gyrus (S. Schurmans et al. (1997) Proc. Natl. Acad. Sci. USA, 94, 10415 ). Here, we investigated dentate LTP induction in mice heterozygous (Cr+/-) for the same mutation. Despite the presence of calretinin in neurons of these mice, although at reduced levels as compared with normal mice, LTP induction in dentate gyrus was totally impaired. Spatial memory and learning were found unaffected in Cr+/- mice, such as in Cr-/- mice. Altogether, our results suggest that calretinin is a critical component in the control of dentate synaptic plasticity in mice, and that levels of calretinin higher than those observed in Cr+/- mice are required to induce LTP in this area. The possible mechanisms leading to the absence of correlation between gene dosage and biological effects are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b79f91ff48b75d475a955741017e460c https://pubmed.ncbi.nlm.nih.gov/9758174 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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