| Autor: |
Douglas Lopes, Almeida, Gabriel Sergio, Fabricio, Laize Peron, Tófolo, Tatiane Aparecida, Ribeiro, Camila Cristina Ianoni, Matiusso, Maiara Vanusa Guedes, Ribeiro, Anna Rebeka, Oliveira Ferreira, Audrei, Pavanello, Ananda, Malta, Kesia, Palma-Rigo, Paulo Cezar, de Freitas Mathias |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of developmental origins of health and disease. 13(3) |
| ISSN: |
2040-1752 |
| Popis: |
Exercise counteracts obesity effects, but information on how early-life obesity may affect long-term adaptation to exercise is lacking. This study investigates the impact of early-life postnatal overfeeding (PO) on animals' adaptation to exercise. Only male Wistar rats were used. On postnatal day (PN) 30, rats from control (NL-9 pups) or PO (SL-3 pups) litters were separated into four groups: NL-sedentary (NL-Se), NL-exercised (NL-Ex), SL-sedentary (SL-Se), and SL-exercised (SL-Ex). Exercised groups performed moderate-intensity exercise, running on a treadmill, from PN30 to PN90. Further experiments were carried out between PN90 and PN92. PO promoted obesity in SL versus NL rats (P0.05). Exercise reduced body weight (P0.001), body fat (P0.01), and improved glucose homeostasis in SL-Ex versus SL-Se. SL-Ex presented lower VO2max (P0.01) and higher post-exercise LDH (P0.05) compared to NL-Ex rats. Although moderate exercise counteracted obesity in SL rats, early-life overnutrition restricts fitness gains in adulthood, indicating that early obesity may impair animals' adaptation to exercise. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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