Progress toward resolving the possible linkage of multiple endocrine neoplasia type 2A to haptoglobin and group-specific loci: use of restriction fragment length polymorphisms extends exclusion region

Autor:	K K, Kidd, J R, Kidd, C M, Castiglione, A J, Pakstis, R S, Sparkes
Rok vydání:	1986
Předmět:	Genetic Markers Polymorphism Genetic Haptoglobins Vitamin D-Binding Protein Multiple Endocrine Neoplasia Chromosome Mapping Humans Chromosomes Human 4-5 DNA Restriction Enzymes Lod Score Blood Protein Electrophoresis Chromosomes Human 16-18
Zdroj:	Genetic epidemiology. 3(3)
ISSN:	0741-0395
Popis:	In an earlier paper, positive but nonsignificant lod scores were found in pair-wise linkage tests between multiple endocrine neoplasia type 2A (MEN-2A) and both the haptoglobin (HP) locus on chromosome 16 and group-specific component (GC) locus on chromosome 4. Recently discovered restriction fragment length polymorphisms for HP and for metallothionein 2 processed pseudogene 1 (MT2P1) near GC have made it possible to carry out a more powerful set of linkage tests with MEN-2A. This paper reports the results of such linkage analyses employing both pair-wise and multipoint tests. Close linkage of HP on chromosome 16 and MEN-2A is excluded. Linkage of MEN-2A on chromosome 4 with GC is excluded on the MT2P1 side of GC in a 7-centimorgan interval around MT2P1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::b70d4b6364d867b43379d1c9aeac5d20 https://pubmed.ncbi.nlm.nih.gov/2873080 Zobrazit plný text záznamu Plný text