| Autor: |
L G, Kolik, V N, Zhukov, S B, Seredenin |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 72(1) |
| ISSN: |
0869-2092 |
| Popis: |
The effects of afobazole (1.0 and 10.0 mg/kg, i.p.) on the antinociceptive properties of morphine (3.0 mg/kg, i.p.) were studied in mice. It is shown that afobazole attenuates the analgesic action of morphine in the "hot plate" and "tail flick" tests. This effect was prevented by sigma 1 receptor antagonist haloperidol (2.0 mg/kg, i.p.). Data obtained suggested that a decrease in the morphine antinociceptive action by afobazole is related to its agonistic interaction with sigma 1 receptors at supraspinal and spinal levels. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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