| Autor: |
Seung Hoon, Lee, Hyung-Jin, Kim, Gi-Su, Oh, Su-Bin, Lee, Dipendra, Khadka, Wal, Cao, Seong-Kyu, Choe, Hyeok, Shim, Chang-Deok, Kim, Tae Hwan, Kwak, Hong-Seob, So |
| Rok vydání: |
2022 |
| Zdroj: |
Journal of inflammation research. 15 |
| ISSN: |
1178-7031 |
| Popis: |
Dunnione has anti-inflammatory properties arising from its ability to alter the ratio of NADPsoriasis-like skin inflammation was generated by daily topical application of IMQ cream. The severity of dermatitis was assessed using the Psoriasis Area Severity Index (PASI) and histochemistry. Expression of inflammatory cytokines was detected by enzyme-linked immunosorbent assay and quantitative PCR. Acetylation of NF-κB p65 and STAT3 was determined by Western blotting.Dunnione improved IMQ-induced epidermal hyperplasia and inflammation, consistent with decreased levels of inflammatory cytokines (IL-17, IL-22, and IL-23) in skin lesions. Moreover, we found that an increase in the NADPharmacological modulation of cellular NAD |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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