Discovery of succinate dehydrogenase candidate fungicides via lead optimization for effective resistance management of

Autor: Sehrish, Iftikhar, Louis, Bengyella, Ahmad Ali, Shahid, Kiran, Nawaz, Waheed, Anwar, Azhar Ali, Khan
Rok vydání: 2021
Předmět:
Zdroj: 3 Biotech
ISSN: 2190-572X
Popis: Fusarium wilt of chili caused by the fungus Fusarium oxysporum f. sp. capsici (FCO) severely reduces the production of chili worldwide. There is growing evidence of resistance to commercial fungicides targeting succinate dehydrogenase (Sdh) of FCO soliciting the development of new Sdh inhibitors (SdhIs). In the current work, optimized docking and virtual screening were used to mine twelve SdhIs from the ZINC database, followed by in vitro antifungal evaluation on spore and radial mycelium development. Four new promising SdhIs exhibiting a mean mycelium inhibition rate greater than 85.6% (F = 155.8, P = 0.001, P
Databáze: OpenAIRE
Externí odkaz: