| Autor: |
E V, Kugaevskaia, Iu E, Eliseeva, L V, Pavlikhina, V N, Orekhovich, I F, Faermark |
| Rok vydání: |
1987 |
| Předmět: |
|
| Zdroj: |
Biulleten' eksperimental'noi biologii i meditsiny. 103(1) |
| ISSN: |
0365-9615 |
| Popis: |
The experiments were carried out to elucidate the effect of carboxycathepsin (CC) activity inhibition by a specific inhibitor--captopril--on plasma enzyme concentration in normotensive rats and rats with renovascular hypertension. A single oral administration of captopril (10 mg/kg body weight) produced an increase in CC concentration in both hypertensive and sodium-depleted normotensive rats with a parallel decrease in arterial pressure, but had no effect on sodium-repleted normotensive rats. It is suggested that the increase in plasma CC concentration is a compensatory response to the inhibition of CC activity by captopril; it is also possible that the increase observed reflects the state of renin-angiotensin system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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