SARS-CoV-2 Infection Dysregulates Cilia and Basal Cell Homeostasis in the Respiratory Epithelium of Hamsters

Autor: Tom, Schreiner, Lisa, Allnoch, Georg, Beythien, Katarzyna, Marek, Kathrin, Becker, Dirk, Schaudien, Stephanie, Stanelle-Bertram, Berfin, Schaumburg, Nancy, Mounogou Kouassi, Sebastian, Beck, Martin, Zickler, Gülsah, Gabriel, Wolfgang, Baumgärtner, Federico, Armando, Malgorzata, Ciurkiewicz
Rok vydání: 2022
Předmět:
Zdroj: International journal of molecular sciences. 23(9)
ISSN: 1422-0067
Popis: Similar to many other respiratory viruses, SARS-CoV-2 targets the ciliated cells of the respiratory epithelium and compromises mucociliary clearance, thereby facilitating spread to the lungs and paving the way for secondary infections. A detailed understanding of mechanism involved in ciliary loss and subsequent regeneration is crucial to assess the possible long-term consequences of COVID-19. The aim of this study was to characterize the sequence of histological and ultrastructural changes observed in the ciliated epithelium during and after SARS-CoV-2 infection in the golden Syrian hamster model. We show that acute infection induces a severe, transient loss of cilia, which is, at least in part, caused by cilia internalization. Internalized cilia colocalize with membrane invaginations, facilitating virus entry into the cell. Infection also results in a progressive decline in cells expressing the regulator of ciliogenesis FOXJ1, which persists beyond virus clearance and the termination of inflammatory changes. Ciliary loss triggers the mobilization of p73
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje