| Autor: |
Abid Ali, Khan, Nafess, Bacha, Bashir, Ahmad, R J, Cox, Jehan, Bakht |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Pakistan journal of pharmaceutical sciences. 29(4) |
| ISSN: |
1011-601X |
| Popis: |
The present study investigates the effect of different growth media and chemical enhancer on silent genes in Aspergillus carbonarius (NRL-369) for secondary metabolites production and its in vitro biological activities. Results revealed that Aspergillus carbonarius (NRL-369) grown in Czapeak yeast extract broth medium produced more metabolites compared with other media. Chemical epigenetic modifiers (suberoyl-anilide hydroxamic acid (SAHA) and 5-azacytidine (5-AZA) at concentration of 15mM were effective for the expression of silent genes resulting in increased secondary metabolites production. Secondary metabolites extracted in ethyl acetate and fractionized in n-Hexane showed variable degree of growth inhibitions of the tested microorganisms. Similarly, these samples were also active against brine shrimps and Lemna. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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