| Autor: |
Celine, Duval, Stephanie, Boucher, Jean-Charles, Moulin, Benedicte, Gourieux, Laurent, Mauvieux, Dominique, Leveque, Raoul, Herbrecht |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Anticancer research. 34(11) |
| ISSN: |
1791-7530 |
| Popis: |
We herein report the case of a male patient with acute myeloid leukemia with fatal outcome attributable to pharmacokinetics of pegfilgrastim.An unexplained blast proliferation in a patient with acute myeloid leukemia following cytotoxic induction chemotherapy was investigated in depth. Myeloblast hyperstimulation was likely related to pegfilgrastim, the long half-life of which extended the duration of side-effects, resulting in massive and rapidly fatal leukemia cell proliferation.Pegfilgrastim can cause unexpected deleterious effects in acute myeloid leukemia. We, thus, recommend administering drugs with a shorter half-life, such as filgrastim or lenograstim, to reduce infection incidence in patients receiving myelosuppressive chemotherapy associated with a clinically significant incidence of febrile neutropenia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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