| Autor: |
Hiroaki, Takeda, Shoichi, Nishise, Tadahisa, Fukui, Shoichiro, Fujishima, Tomohiko, Orii, Sayaka, Otake, Takeshi, Sato, Yu, Sasaki, Sumio, Kawata |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Hepato-gastroenterology. 56(90) |
| ISSN: |
0172-6390 |
| Popis: |
Cytapheresis with extra-corporeal circulation for ulcerative colitis is effective but its mechanisms are still unclear. Granulocytecolony stimulating factor (G-CSF) strongly mobilizes bone marrow-derived cells and serves as antiinflammatory factor. We investigated plasma levels of G-CSF during granulocyte and monocyte adsorptive apheresis (GCAP).Nineteen cases of ulcerative colitis were measured plasma concentration of G-CSF during the first session of GCAP therapy.G-CSF were significantly increased in the column inflow at 30 min compared with the baseline (Wilcoxon test, p0.01), and also increased through the column (Wilcoxon test, p0.01). The ratio of the increase in the column outflow at 60 min was 1.5-fold compared with the baseline. However, we could not show a significant relation between G-CSF level and clinical efficacy.This is the first report concerning G-CSF during CAP. G-CSF is increased due to GCAP and appears to be a candidate which should be further investigated. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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