Transplantation tolerance induced by CTLA4-Ig
| Autor: | T C, Pearson, D Z, Alexander, K J, Winn, P S, Linsley, R P, Lowry, C P, Larsen |
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| Rok vydání: | 1994 |
| Předmět: |
Immunosuppression Therapy
Male Mice Inbred BALB C Mice Inbred C3H Immunoconjugates Time Factors Recombinant Fusion Proteins T-Lymphocytes Graft Survival Antibodies Monoclonal Antigens Differentiation Abatacept Mice Inbred C57BL Mice Antigens CD Animals Heart Transplantation Humans Transplantation Homologous CTLA-4 Antigen Immunoglobulin Heavy Chains |
| Zdroj: | Transplantation. 57(12) |
| ISSN: | 0041-1337 |
| Popis: | The rejection of the transplanted allograft is dependent on T cell activation, which requires T cell receptor engagement by antigen and costimulatory signals delivered by T cell surface molecules such as CD28. CTLA4-Ig is a fusion protein that has previously been shown to block the CD28-mediated costimulatory signal and inhibit immune responses in vitro and in vivo. In this report we show that treatment of the C3H/He recipient of a BALB/c vascularized cardiac allograft with a 12-day course of CTLA4-Ig produced indefinite graft survival (100 days) in the majority of recipients. In addition, these recipients demonstrated donor-specific transplantation tolerance when tested with donor-specific (BALB/c) and third-party (C57BL/10) skin grafts. These results demonstrate that CTLA4-Ig can induce transplantation tolerance in the adult murine cardiac allograft model. |
| Databáze: | OpenAIRE |
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