A Feasibility Study of Neoadjuvant XELOX Without Radiotherapy for Locally Advanced Lower Rectal Cancer
| Autor: | Takashi, Ueki, Tatsuya, Manabe, Shigetaka, Inoue, Jun, Ienaga, Naoki, Yamanaka, Takuya, Egami, Mikimasa, Ishikawa, Hiroyuki, Konomi, Akashi, Ikubo, Kinuko, Nagayoshi, Masafumi, Nakamura, Masao, Tanaka |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Aged 80 and over Male Neoplasm Residual Time Factors Oxaloacetates Rectal Neoplasms Carcinoma Pilot Projects Middle Aged Deoxycytidine Neoadjuvant Therapy Young Adult Treatment Outcome Japan Chemotherapy Adjuvant Antineoplastic Combined Chemotherapy Protocols Feasibility Studies Humans Female Fluorouracil Prospective Studies Capecitabine Aged Neoplasm Staging |
| Zdroj: | Anticancer research. 36(2) |
| ISSN: | 1791-7530 |
| Popis: | This study was planned to evaluate the efficacy and safety of preoperative capecitabine and oxaliplatin (XELOX) without radiation in patients with locally advanced lower rectal cancer.Patients with clinical stage II/III lower rectal cancer underwent three cycles of XELOX followed by radical surgery. The primary end-point was the R0 resection rate.Thirty-one patients were recruited between February 2012 and August 2014. The completion rate of neoadjuvant chemotherapy was 96.5% among the 29 patients who received it; the remaining two refused chemotherapy and underwent immediate surgery. Grade 3-4 adverse events occurred in nine patients (31%). All 29 patients who received chemotherapy underwent radical resection. The R0 resection rate was 96.5% among these 29 patients. Pathological complete responses were achieved in three patients (10.3%) and downstaging occurred in 13 (44.8%).This pilot study found that neoadjuvant XELOX for locally advanced lower rectal cancer is feasible and safe. This neoadjuvant treatment improved resection margin status. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|