Reverse cholesterol transport and future pharmacological approaches to the treatment of atherosclerosis
| Autor: | B R, Krause, B J, Auerbach |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
CD36 Antigens
Biological Transport Active Coronary Artery Disease Phosphatidylcholine-Sterol O-Acyltransferase Mice Animals Humans Intestinal Mucosa Receptors Immunologic Triglycerides Glycoproteins Receptors Lipoprotein Mice Knockout Receptors Scavenger Apolipoprotein A-I Cholesterol HDL Membrane Proteins Scavenger Receptors Class B Cholesterol Ester Transfer Proteins Up-Regulation Disease Models Animal Cholesterol Liver Gene Targeting ATP-Binding Cassette Transporters Cholesterol Esters Carrier Proteins |
| Zdroj: | Current opinion in investigational drugs (London, England : 2000). 2(3) |
| ISSN: | 1472-4472 |
| Popis: | The apparent protective effect of high density lipoprotein cholesterol (HDL) with respect to coronary heart disease (CHD) is generally thought to reside in its ability to transport cholesterol from peripheral cells to the liver for excretion from the body. Knozon as reverse cholesterol transport (RCT), this process involves many key steps and lipoprotein interconversions, and there is no consensus as to which step is most suitable for possible drug intervention. The membrane proteins, scavenger receptor class B, type 1 (SR-B1) and the ATP-binding cassette 1 (ABC1), have been strongly implicated as being important in cholesterol efflux; the former as a bona fide receptor for HDL and the latter as a lipid transporter. Lecithin:cholesterol acyltransferase (LCAT) then esterifies the effluxed cholesterol to form cholesteryl esters (Step 2), which are then transferred to apoB-containing lipoproteins by cholesteryl ester transfer protein (CETP, Step 3). Despite the complexities and uncertainties, drugs should be developed which impact all of the above steps, and short-term endpoints need to be defined for a cautious, systematic approach to clinical evaluation. |
| Databáze: | OpenAIRE |
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