| Autor: |
L C, Dai, C N, Wang, J F, He, J P, Qian, W H, Wang, B N, Shi |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology. 20(3) |
| ISSN: |
1003-9279 |
| Popis: |
To explore the significance of HBV large envelope protein (LHBs) in diagnosing HBV replication in chronic hepatitis B patients.Serum HBV DNA was quantitively detected by using real-time polymerase chain reaction (RT-PCR), the LHBs and Pre-S1 were detected by using enzyme linked immunosorbent assay (ELISA) and HBV markers were detected by time differentiate immunofluorescence assay in 340 serum samples collected from chronic hepatitis B patients.Serum LHBs level was closely correlated with number of HBV DNA copies (r=0.899, P=0.0380). There was no significant difference between positive rate of LHBs and that of HBV DNA in different HBeAg pattern (P0.05); the positive rate of LHBs was 83.15%, which was higher than that of Pre-S1 and HBeAg which were 50.54% and 54.48%, respectively. There was significant difference (P less than 0.05).The level of serum LHBs can be used to estimate the state of HBV replication and the sensitivity was superior to both Pre-S1 and HBeAg. So it may be used as a new serological marker to detect HBV replication. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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