| Autor: |
Carl, Edin, Mattias, Ekstedt, Tobias, Scheffel, Markus, Karlsson, Eva, Swahn, Carl Johan, Östgren, Jan, Engvall, Tino, Ebbers, Olof Dahlqvist, Leinhard, Peter, Lundberg, Carl-Johan, Carlhäll |
| Rok vydání: |
2021 |
| Zdroj: |
Frontiers in cardiovascular medicine. 9 |
| ISSN: |
2297-055X |
| Popis: |
Different regional depots of fat have distinct metabolic properties and may relate differently to adverse cardiac remodeling. We sought to quantify regional depots of body fat and to investigate their relationship to cardiac structure and function in Type 2 Diabetes (T2D) and controls.From the SCAPIS cohort in Linköping, Sweden, we recruited 92 subjects (35% female, mean age 59.5 ± 4.6 years): 46 with T2D and 46 matched controls. In addition to the core SCAPIS data collection, participants underwent a comprehensive magnetic resonance imaging examination at 1.5 T for assessment of left ventricular (LV) structure and function (end-diastolic volume, mass, concentricity, ejection fraction), as well as regional body composition (liver proton density fat fraction, visceral adipose tissue, abdominal subcutaneous adipose tissue, thigh muscle fat infiltration, fat tissue-free thigh muscle volume and epicardial adipose tissue).Compared to the control group, the T2D group had increased: visceral adipose tissue volume index (Ectopic fat is predominantly associated with cardiac remodeling, independently of type 2 diabetes. Intriguingly, liver fat appears to be related to LV structure independently of VAT, while epicardial fat is linked to impaired LV diastolic function. Visceral fat is associated with T2D independently of liver fat and abdominal subcutaneous adipose tissue. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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