[Effect of electroacupuncture on amyotrophia and expression of myogenic differentiation-related genes of gastrocnemius in rats with chronic constriction injury of sciatic nerve]

Autor: Dan-Dan, Zhao, Cheng-Lin, Tang, Si-Qin, Huang, Ao, Luo, An-Ning, Zhang, Meng-Jia, Wu, Hui-Yu, An, Cheng-Fang, Tan, Li, Qiu
Rok vydání: 2019
Předmět:
Zdroj: Zhen ci yan jiu = Acupuncture research. 44(1)
ISSN: 1000-0607
Popis: To explore the effect of electroacupuncture(EA) on amyotrophia and expression of paired box7(Pax7), myogenic differentiation antigen-1 (Myod1), myogenin (Myog), myosin heavy chain- Ⅱa (Myh2), myosin heavy chain-Ⅱx (Myh1) and myosin heavy chain-Ⅰ (Myh7) of denervated gastrocnemius in rats with chronic constriction injury (CCI) of the right sciatic nerve, so as to explore its mechanisms underlying postponing development of amyotrophia.Sixty-six SD adult male rats were randomly divided into sham operation (sham) group (After 1 week of modeling, the ratios of wet weight of gastrocnemius and the CSA and fiber diameter at the 2EA treatment may delay gastrocnemius atrophy in CCI rats, which is possibly associated with its effects in up-regulating the expression of Myod1, Myog and Myh7 mRNAs to control the differentiation of the satellite cells and the muscle fiber type transformation.
Databáze: OpenAIRE