| Autor: |
Anna, Stiepanow-Trzeciak, Maciej, Jankowski, Stefan, Angielski, Miroslawa, Szczepanska-Konkel |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Nephron. Physiology. 106(1) |
| ISSN: |
1660-2137 |
| Popis: |
P1,P4-diadenosine tetraphosphate (Ap4A) is a vasoactive dinucleotide possessing natriuretic activity. It is unclear, however, which part of the nephron is the target site of action for Ap4A.We evaluated the tubular sites of Ap4A action using the lithium clearance technique.Ap4A at a priming dose of 2 micromol/kg with subsequent infusion at 20 nmol/kg/min increased fractional water and sodium excretion 2.5- and 5.6-fold, respectively. Moreover, Ap4A increased lithium clearance 1.9-fold and fractional lithium excretion 2.8-fold. Fractional water and sodium excretion from distal nephron segments was not significantly affected by Ap4A.These results suggest that Ap4A induces natriuresis mainly through inhibition of proximal tubular reabsorption of sodium. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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