The sequential analysis of trisomy 12 in B-cell chronic lymphocytic leukaemia

Autor:	R L, Auer, N, Bienz, J, Neilson, M, Cai, J J, Waters, D W, Milligan, C D, Fegan
Rok vydání:	1999
Předmět:	Chromosomes Human Pair 12 Humans Trisomy Longitudinal Studies Leukemia Lymphocytic Chronic B-Cell In Situ Hybridization Fluorescence Follow-Up Studies
Zdroj:	British journal of haematology. 104(4)
ISSN:	0007-1048
Popis:	In this longitudinal study we evaluated the clinical significance of screening for trisomy 12 by fluorescence in situ hybridization (FISH) and correlated these findings with survival, disease progression and need for treatment. Interphase FISH was performed on 85 patients in 1993/94 and repeated on 41 patients in 1996/97. Over the 4-year period there was no significant change in the percentage of trisomic cells, even in patients with disease progression. Overall survival and requirement for treatment were similar for patients with and without FISH-defined trisomy 12.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9c9d2521f3e701282dd6dc75deb56e53 https://pubmed.ncbi.nlm.nih.gov/10192434 Zobrazit plný text záznamu Plný text