Studies on the terminal stages of antibody-complement-mediated killing of a tumor cell. I. Evidence for the existence of an intermediate, T

Autor: M D, Boyle, S H, Ohanian, T, Borsos
Rok vydání: 1976
Předmět:
Zdroj: Journal of immunology (Baltimore, Md. : 1950). 116(5)
ISSN: 0022-1767
Popis: The mechanism of the terminal steps in the lysis of antibody-sensitized tumor cells by complement (TAC) was studied. It was shown that once complement has reacted, lysis proceeded even in the absence of fluid-phase complement. Transformation of TAC to dead cells was found to be at least a two-step process: one of the steps was temperature dependent whereas the other was reversibly inhibited by EDTA. In analogy to the hemolytic system, TAC has been designated T.
Databáze: OpenAIRE