Monte Carlo simulation of radiation transport and dose deposition from locally released gold nanoparticles labeled with
| Autor: | Priscilla, Lai, Zhongli, Cai, Jean-Philippe, Pignol, Eli, Lechtman, Shahram, Mashouf, Yijie, Lu, Mitchell A, Winnik, David A, Jaffray, Raymond M, Reilly |
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| Rok vydání: | 2017 |
| Předmět: |
Single Photon Emission Computed Tomography Computed Tomography
Brachytherapy Indium Radioisotopes Metal Nanoparticles Breast Neoplasms Radiotherapy Dosage Mice SCID Lutetium Xenograft Model Antitumor Assays Mice Tumor Cells Cultured Animals Humans Female Yttrium Radioisotopes Gold Radiometry Monte Carlo Method |
| Zdroj: | Physics in medicine and biology. 62(22) |
| ISSN: | 1361-6560 |
| Popis: | Permanent seed implantation (PSI) brachytherapy is a highly conformal form of radiation therapy but is challenged with dose inhomogeneity due to its utilization of low energy radiation sources. Gold nanoparticles (AuNP) conjugated with electron emitting radionuclides have recently been developed as a novel form of brachytherapy and can aid in homogenizing dose through physical distribution of radiolabeled AuNP when injected intratumorally (IT) in suspension. However, the distribution is unpredictable and precise placement of many injections would be difficult. Previously, we reported the design of a nanoparticle depot (NPD) that can be implanted using PSI techniques and which facilitates controlled release of AuNP. We report here the 3D dose distribution resulting from a NPD incorporating AuNP labeled with electron emitters ( |
| Databáze: | OpenAIRE |
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