Different calcium requirements during incorporation of myo-inositol into membrane lipids for phosphatidylinositol hydrolysis stimulated by carbachol and noradrenaline

Autor: I, Nalepa, E, Chalecka-Franaszek, J, Vetulani
Rok vydání: 1990
Předmět:
Zdroj: Polish journal of pharmacology and pharmacy. 42(4)
ISSN: 0301-0244
Popis: Stimulation of phosphatidylinositol hydrolysis by noradrenaline requires the presence of calcium in the medium during the whole incubation and preincubation procedure, while carbachol-induced inositol phosphate formation is equally efficient in calcium-free and calcium-containing medium. This finding confirms the notion that phosphatidylinositols mobilized after stimulation of various receptors are present in different metabolic pools: the pool mobilized by alpha 1 adrenoceptors is apparently formed from myo-inositol incorporated into membrane phospholipids by a calcium-dependent process.
Databáze: OpenAIRE