Etodolac nanosuspension based gel for enhanced dermal delivery

Autor:	Alptug, Karakucuk, Serdar, Tort, Sevtap, Han, Ayse Nur, Oktay, Nevin, Celebi
Rok vydání:	2021
Předmět:	Male Drug Delivery Systems Skin Absorption Anti-Inflammatory Agents Non-Steroidal Animals Etodolac Nanoparticles In Vitro Techniques Rats Wistar Gels Rats
Zdroj:	Journal of microencapsulation. 38(4)
ISSN:	1464-5246
Popis:	The objective of this study was to develop dermal nanosuspension (NS) based gel formulation of etodolac (ETD).Etodolac nanosuspension (ETD-NS) was prepared by wet milling method and dispersed in hydroxypropyl methylcellulose (NS-HPMC) or hydroxyethyl cellulose (NS-HEC) gels. Rheologic and mechanical properties were investigated.The ETD-NS with approximately 190 nm particle size (PS), 0.16 polydispersity index (PDI), and -15 mV zeta potential (ZP) values were obtained. The work of bioadhesion values of NS-HEC and NS-HPMC gels were 0.229 mJ/cmETD-NS based gel formulation is promising for topical delivery of ETD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::97acab04b3647df18cebf4dff38ac0b8 https://pubmed.ncbi.nlm.nih.gov/33752553 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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