| Autor: |
Robin J, Lurvink, Rudaba, Tajzai, Koen P, Rovers, Emma C E, Wassenaar, Dirk-Jan A R, Moes, Giulia, Pluimakers, Djamila, Boerma, Jacobus W A, Burger, Simon W, Nienhuijs, Ignace H J T, de Hingh, Maarten J, Deenen |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Annals of surgical oncology. 28(1) |
| ISSN: |
1534-4681 |
| Popis: |
Electrostatic pressurized intraperitoneal aerosol chemotherapy (ePIPAC) is a palliative treatment for unresectable peritoneal metastases from various primary cancers. However, little is known about the systemic pharmacokinetics of oxaliplatin after ePIPAC.Twenty patients with unresectable colorectal peritoneal metastases were treated with repetitive ePIPAC monotherapy with oxaliplatin (92 mg/mFour patients received one ePIPAC, three patients received two ePIPAC, and thirteen patients received ≥ 3 ePIPAC. The population pharmacokinetic models adequately described the pharmacokinetics of oxaliplatin after ePIPAC. The plasma ultrafiltrate CSystemic exposure to oxaliplatin after ePIPAC seemed comparable to that after systemic chemotherapy, as described in other literature. Since this is an indirect comparison, future research should focus on the direct comparison between the systemic exposure to oxaliplatin after ePIPAC and after systemic chemotherapy.NCT03246321, Pre-results; ISRCTN89947480, Pre-results; NTR6603, Pre-results; EudraCT: 2017-000927-29, Pre-results. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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