| Autor: |
Xue-Ling, He, Guang, Yang, Hai-Lin, Yin, Xue-Me, Zhang |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 40(1) |
| ISSN: |
1672-173X |
| Popis: |
To study the pharmacokinetics and tissue distribution of PEG-rhIL-6 in rats after a single dose administration.Pharmacokinetics and distribution of PEG-rhIL-6 in rats were studied by 125I isotope tracing method. Pharmacokinetic analysis was performed using 3P97 computer software.PEG-rhIL-6 declined in one-compartment model with half-lives of 10.44-11.37 h for t1/2 Ka, 19.77-21.53 h for t1/2 Ke and 20.51-21.96 h for T(pcak), respectively. PEG-rhIL-6 was mainly distributed in blood and excreted via urine.The half-lives of PEG-rhIL-6 are prolonged after being modified by PEG. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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