| Autor: |
Xin-Xin, Chen, Xiao-Yun, Zhang, Yu-Zhen, Ding, Xin, Li, Xiu-Mei, Guan, Hong, Li, Min, Cheng, Xiao-Dong, Cui |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 34(5) |
| ISSN: |
1000-6834 |
| Popis: |
To investigate the effects of endothelial progenitor cells (EPCs) under shear stress on the biological function such as proliferation, adhesion, migration, apoptosis and expression of α-smooth muscle actin (α-SMA), collagen-I and collagen-Ⅲ of hepatic stellate cells (HSCs).HSCs and EPCs were inoculated into the upper and lower layers of the co-culture chamber respectively and co-incubated for 24 hours. Then, 12 dyne/cmUnder shear stress, EPCs ecological niche could obviously inhibit the proliferation, adhesion and migration of HSCs, promote the apoptosis of HSCs, and down-regulate the mRNA and protein expression of collagen-I, collagen-Ⅲ in HSC cells.Under shear stress, EPCs ecological niche could inhibit the fibrosis development of HSCs to a certain extent. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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