| Autor: |
T I, Kulak, E I, Kvasiuk, S L, Sentiureva, S M, Shuliakovskaia, V P, Matiushevskaia, M V, Makarenko, I A, Mikhaĭlopulo |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Bioorganicheskaia khimiia. 25(9) |
| ISSN: |
0132-3423 |
| Popis: |
To elucidate the antibody-(2'-5')oligoadenylate relation to the mode of the hapten-immunogen conjugation, a new (2'-5')oligoadenylic acid trimer derivative containing a 2'-terminal N6-(5-carboxypentyl)adenosine and its 125I-labeled immunogenic conjugate were synthesized. The immunization with this conjugate and with a conjugate based on the 2',3'-O-[1-(2-carboxyethyl)]ethylidene derivative of the (2'-5')triadenylic acid gave antisera with different affinities toward modified (2'-5')oligonucleotides. Epitopes involved in the (2'-5')oligomer-binding to different antisera were found. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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