| Autor: |
Youwu, Shi, Shengyu, Zhou, Xiaohui, He, Xiaohong, Han, Shikai, Wu, Feng, Pan, Peng, Liu, Yinyu, Liu, Yingheng, Lei, Hongzhi, Zhang, Jianliang, Yang, Yan, Qin, Changgong, Zhang, Sheng, Yang, Liya, Zhao, Kehuan, Luo, Guanqing, Wu, Yan, Sun, Yuankai, Shi |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu. 27(1) |
| ISSN: |
1000-9604 |
| Popis: |
The study evaluated the effectiveness of autologous hematopoietic stem cell transplantation (AHSCT) in the treatment of lymphoblastic lymphoma (LL).We retrospectively analyzed the data from 41 patients with chemotherapy-sensitive LL who underwent hematopoietic stem cell transplantation (HSCT) from December 1989 to December 2009 in a single institution.HSCT was conducted as first-line consolidation therapy and salvage therapy in 36 and 5 patients, respectively. The median follow-up was 97.1 months (range, 24.6-173.1 months). The 5-year overall survival (OS) and event-free survival (EFS) rate were 64% and 47% for the initially treated patients, respectively, and were both 20% for the relapsed ones. Bone marrow (BM) involvement and chemotherapy cycles prior to transplantation were identified as significant prognostic factors for EFS in multivariate analysis.These results confirm that AHSCT is a reasonable option for chemotherapy-sensitive LL patients in first complete remission (CR1). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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