Autoimmune basis for visual paraneoplastic syndrome in patients with small cell lung carcinoma. Retinal immune deposits and ablation of retinal ganglion cells

Autor:	G B, Grunwald, S E, Kornguth, J, Towfighi, J, Sassani, M A, Simmonds, C M, Housman, N, Papadopoulos
Rok vydání:	1987
Předmět:	Male Retinal Ganglion Cells Lung Neoplasms Antibodies Neoplasm Histocytochemistry Paraneoplastic Syndromes Vision Disorders Fluorescent Antibody Technique Antigen-Antibody Complex Retina Autoimmune Diseases Humans Carcinoma Small Cell Aged
Zdroj:	Cancer. 60(4)
ISSN:	0008-543X
Popis:	Recently, patients with visual paraneoplastic syndrome (VPS) were described, a binocular loss of vision found in patients with small cell carcinoma of the lung (SCCL). The patients have serum antibodies against a small number of discrete antigens which are shared by the retina and small cell carcinoma cells, and which are associated with cells and processes of the ganglion cell layer of the retina. Pathologic findings are presented with regard to the presence of immunoglobulins in, and the nature of the lesions in, the central nervous system of a VPS patient. The patient's blood-brain barrier was shown to be compromised, as demonstrated by the finding of high immunoglobulin levels in the cerebrospinal fluid and immune deposits in the retina. It is further shown that within the central nervous system only the retina and optic nerve show any tissue damage with the specific loss of retinal ganglion cells and their processes. The findings support the hypothesis of an autoimmune cause for this remote effect of cancer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::924fbc7a48e1ed4331a608f3b1e2d6d9 https://pubmed.ncbi.nlm.nih.gov/3036336 Zobrazit plný text záznamu Plný text