| Autor: |
Feifei, Xie, Xin, Zhen, Zhuoliang, Liu, Xiaomei, Chen, Zhuanhua, Liu, Miaomiao, Zhou, Zhanmei, Zhou, Zheng, Hu, Fengxin, Zhu, Qiaobing, Huang, Lei, Zhang, Jing, Nie |
| Rok vydání: |
2022 |
| Zdroj: |
Frontiers in physiology. 13 |
| ISSN: |
1664-042X |
| Popis: |
Chronic kidney disease (CKD) is a global public health problem that shortens lifespan primarily by increasing the risk of cardiovascular diseases. Trimethylamine-N-oxide (TMAO), a gut microbiota-derived toxin produced by metabolizing high-choline or carnitine foods, is associated with cardiovascular events in patients with CKD. Although the deleterious effect of TMAO on CKD-induced cardiac injury has been confirmed by various researches, the mechanisms remain unclear. Here, we tested the hypothesis that TMAO aggravates CKD-induced cardiac injury and explores the potential mechanism. CD1 mice underwent 5/6 nephrectomy to induce CKD, and then fed with a diet supplemented with choline (1.2% total) for 8 weeks. Serum TMAO levels were elevated in CKD mice compared with SHAM group, and higher TMAO levels were found in choline-supplemented CKD mice compared with CKD group. Dietary choline aggravated CKD-induced cardiac dysfunction, and reducing TMAO levels |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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