| Autor: |
C W, So, Z G, Ma, C M, Price, S, Dong, S J, Chen, L J, Gu, C K, So, L M, Wiedemann, L C, Chan |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Cancer research. 57(1) |
| ISSN: |
0008-5472 |
| Popis: |
Fifty-six patients with de novo acute myeloid leukemia M4/M5 subtypes were studied for rearrangements of the mixed lineage leukemia gene, MLL (also called HRX, Htrx-1, or ALL-1). Ten patients (18%) showed rearrangements of the MLL gene, 9 in a major breakpoint cluster region within a centromeric 8.3-kb BamHI fragment, whereas rearrangement in one patient was the result of a direct tandem duplication of exons 2-6 of MLL. Analysis of sequences at the duplication junction revealed that the points of MLL fusion within introns 6 and 1 both lie within Alu elements. This suggests the involvement of Alu repeat mediated homologous recombination in MLL self fusion. For the 10 rearranged samples, cytogenetics analysis revealed a normal karyotype in 3, and 3 had abnormalities other than 11q23. Survival analysis of patients revealed no difference between those with rearrangement of MLL and those showing the germ-line configuration. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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