| Autor: |
Zhuo-Er, Qiu, Lei, Chen, Xiao-Chun, Hou, Jie, Sheng, Jian-Bang, Xu, Jia-Wen, Xu, Dong-Dong, Gao, Ze-Xin, Huang, Tian-Lun, Lei, Zi-Yang, Huang, Lei, Peng, Hai-Long, Yang, Qin-Hua, Lin, Yun-Xin, Zhu, Wei-Jie, Guan, Zhao-Rong, Lun, Wen-Liang, Zhou, Yi-Lin, Zhang |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
The Journal of infection. 86(1) |
| ISSN: |
1532-2742 |
| Popis: |
Toxoplasma gondii is a widespread parasitic protozoan causing toxoplasmosis including pulmonary toxoplasmosis. As the first line of host defense, airway epithelial cells play critical roles in orchestrating pulmonary innate immunity. However, the mechanism underlying the airway inflammation induced by the T. gondii infection remains largely unclear. This study demonstrated that after infection with T. gondii, the major anion channel located in the apical membranes of airway epithelial cells, cystic fibrosis transmembrane conductance regulator (CFTR), was degraded by the parasite-secreted cysteine proteases. The intracellular Cl |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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