| Autor: |
Biagio, Palmisano, Rossella, Labella, Samantha, Donsante, Cristina, Remoli, Emanuela, Spica, Ilenia, Coletta, Giorgia, Farinacci, Michele, Dello Spedale Venti, Isabella, Saggio, Marta, Serafini, Pamela Gehron, Robey, Alessandro, Corsi, Mara, Riminucci |
| Rok vydání: |
2021 |
| Zdroj: |
Bone research. 10(1) |
| ISSN: |
2095-4700 |
| Popis: |
The Gsα/cAMP signaling pathway mediates the effect of a variety of hormones and factors that regulate the homeostasis of the post-natal skeleton. Hence, the dysregulated activity of Gsα due to gain-of-function mutations (R201C/R201H) results in severe architectural and functional derangements of the entire bone/bone marrow organ. While the consequences of gain-of-function mutations of Gsα have been extensively investigated in osteoblasts and in bone marrow osteoprogenitor cells at various differentiation stages, their effect in adipogenically-committed bone marrow stromal cells has remained unaddressed. We generated a mouse model with expression of Gsα |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
