PBG-synthetase activity in the liver of Yoshida sarcoma-bearing rats

Autor: L D, Rubert, C, de la Piedra, H J, Castro Mendoza
Rok vydání: 1979
Předmět:
Zdroj: Biomedicine / [publiee pour l'A.A.I.C.I.G.]. 31(3)
ISSN: 0300-0893
Popis: The etiology of anemia in cancer is not fully understood. A possible cause of the anemia of tumor-bearing animals could be a decreased activity in the enzymes of the heme-pathway. We report the enzyme activity of porphobilinogen-synthetase in the liver of Yoshida sarcoma-bearing rats. PBG-synthetase activity in the whole liver, is higher in tumor-bearing rats than in controls, although the enzyme activity by a gram of wet liver is decreased. Hence PBG-synthetase activity is not a limiting factor in the biosynthesis of heme in tumor-bearing animals.
Databáze: OpenAIRE