Role of
| Autor: | Vikas, Kailashiya, Hanjabam Barun, Sharma, Jyotsna, Kailashiya |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Journal of clinical pathology. 72(10) |
| ISSN: | 1472-4146 |
| Popis: | CTLA-4 (cytotoxic T-lymphocyte-associated protein-4) or CD152 is an inhibitory receptor expressed constitutively on CD4+ CD25+ T regulatory lymphocytes and transiently on activated CD4+ and CD8+ T lymphocytes. Its inhibitory function promotes long-lived anergy in immune cells and prevents autoimmunity. Therefore, it plays a crucial role in T cell-mediated autoimmunity, and thus in susceptibility to autoimmune diseases, including systemic lupus erythematosus (SLE). It is encoded by |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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