| Autor: |
L, Provitera, G, Cavallaro, A, Griggio, G, Raffaeli, I, Amodeo, S, Gulden, D, Lattuada, G, Ercoli, C, Lonati, A, Tomaselli, F, Mosca, E, Villamor |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 70(4) |
| ISSN: |
1899-1505 |
| Popis: |
Umbilical vessels have a low sensitivity to dilate, and this property is speculated to have physiological implications. We aimed to investigate the different relaxing responses of human umbilical arteries (HUAs) and veins (HUVs) to agonists acting through the cAMP and cGMP pathways. Vascular rings were suspended in organ baths for isometric force measurement. Following precontraction with the thromboxane prostanoid (TP) receptor agonist U44069, concentration-response curves to the nitric oxide (NO) donor sodium nitroprusside (SNP), the soluble guanylate cyclase (sGC) stimulator BAY 41-2272, the adenylate cyclase (AC) activator forskolin, the β-adrenergic receptor agonists isoproterenol (ADRB1), salmeterol (ADRB2), and BRL37344 (ADRB3), and the phosphodiesterase (PDE) inhibitors milrinone (PDE |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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