| Autor: |
N M, Nasybullina, V I, Gunar, V P, Zherdev, A K, Sariev, G S, Kozlova, R S, Mirzoian, T S, Gan'shina, A L, Karaev |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 60(2) |
| ISSN: |
0869-2092 |
| Popis: |
The permeability through the blood-brain barrier of N-(4-hydroxy-3,3 dimethyl-2-oxo-1-butiryl) gamma-aminobutyric acid calcium salt, a new neurotropic drug calcium ketohomopantothenate (KPA-Ca), was studied in comparison with that of calcium homopantothenate, pantogam (P) Liquid chromatography analysis showed that after oral administration of KPA-Ca and P both forms of these agents, namely, oxy- and keto- derivatives of homopantothenic acid, were found in the brain of experimental rats, the KPA-Ca (ketoform) content being higher. Pharmacological studies showed that KPA-Ca penetrates the blood-brain barrier in greater amounts and causes a higher effect on the rate of cerebral blood flow when it is administered per os in a dose of 50 mg/kg. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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